Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.

ABSTRACT:

Background

Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol involvement, and extent of shared genetic liability remain unclear. We estimate longitudinal associations between transitions among alcohol milestones, behavioral phenotypes, and indices of genetic risk.

Methods

Data came from the Collaborative Study on the Genetics of Alcoholism (n = 3681; ages 11-36). Alcohol transitions (first: drink, intoxication, alcohol use disorder [AUD] symptom, AUD diagnosis), internalizing, and externalizing phenotypes came from the Semi-Structured Assessment for the Genetics of Alcoholism. EF was measured

SUBMITTER: Paul SE 

PROVIDER: S-EPMC11464200 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature