Synthesis and biological evaluation of burnettiene A derivatives enabling discovery of novel fungicide candidates.

ABSTRACT: An antifungal polyene-decalin polyketide natural product, burnettiene A (1) has been re-discovered from the culture broth of Lecanicillium primulinum (current name: Flavocillium primulinum) FKI-6715 strain utilizing our original multidrug-sensitive yeast system. This polyene-decalin polyketide natural product was originally isolated from Aspergillus burnettii. The antifungal activity of 1 against Candida albicans has been reported. However, only one fungal species for the antifungal activity of 1 has been revealed, and details of the antifungal activity against other pathogenic fungus remain unknown. After extensive screening for antifungal activity, we found that 1 exhibits broad antifungal activity against pathogenic plant fungi, in

SUBMITTER: Kimishima A 

PROVIDER: S-EPMC11464271 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature