Genetically predicted Caspase 8 levels mediates the causal association between CD4+ T cell and breast cancer.

ABSTRACT:

Background

Breast cancer (BC) remains a significant contributor to female mortality globally, with inflammation and the immune system implicated in its pathogenesis. To elucidate potential causal relationships, we evaluated the relationship among 731 immune cell phenotypes and BC be at risk by using Mendelian randomization (MR), while also exploring inflammatory proteins as mediators in this association.

Methods

We obtained immune cell genome-wide association study (GWAS) summary data and 91 inflammatory factors from the GWAS Catalog. BC GWAS data was obtained from the IEU Open GWAS project (ukb-b-16890 for discovery and GCST004988 for validation). We investigated the causal link between immune cells and BC risk by employing a two-sample MR method. Furthermore, we use a two-

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11464308 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature