Integrated metabolomic and transcriptomic analyses of <i>Dendrobium chrysotoxum</i> and <i>D. thyrsiflorum</i> reveal the biosynthetic pathway from gigantol to erianin.

ABSTRACT: Erianin is one of the most representative bibenzyls with significant inhibitory activity against a wide range of tumor cells. However, the low erianin level in natural materials has severely inhibited its further development in health care. Our aim was to uncover the erianin biosynthetic pathway to lay the foundation for promoting its production. Firstly, we screened and obtained two Dendrobium species (Dendrobium thyrsiflorum stems with lower erianin content and D. chrysotoxum stems with higher erianin content), belonging to the same Dendrobium section (Chrysotoxae). A systematic analysis of bibenzyl structure and content in two stems revealed that gigantol might be an erianin biosynthetic intermediate, which was verified by introducing deuterium-labeled gigant

SUBMITTER: Xie L 

PROVIDER: S-EPMC11464314 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature