Sphingosine 1-phosphate receptor 2 in keratinocytes plays a key role in reducing inflammation in psoriasis.

ABSTRACT:

Background

Psoriasis is an inflammatory skin condition where immune cells play a significant role. The importance of the cross-talk between keratinocytes and immune cells in the pathogenesis of psoriasis has recently been reaffirmed. Recent studies have found that several S1PR functional antagonists, other than S1PR2, are effective in improving psoriasis. This study aims to investigate the role of S1PR2 in psoriasis, that has not been investigated before.

Methods

Spatial transcriptomics, RT-qPCR, and flow cytometry were used to map the immune cell landscape and its association with metabolic pathways in an imiquimod (IMQ)-induced psoriasis-like inflammation in S1pr2^fl/fl K14-Cre mice that could not sense sphingosine-1-phosphate (S1P) in the epidermis throug

SUBMITTER: Masuda-Kuroki K 

PROVIDER: S-EPMC11464331 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature