JN.1: enhanced immune evasion ability propels it to become the predominant strain in China, unlikely to trigger pandemic similar to late 2022.

ABSTRACT:

Introduction

Due to the widespread presence of susceptible populations, the pandemic caused by BA.5 subbranches swiftly disseminated China, impacting the majority of individuals within a span of 1 to 2 months. Subsequently, XBB and its subbranches became the dominant variants in China.

Methods

We tracked the immune landscape in the population after the SARS-CoV-2 pandemic in late 2022 in China.

Results

Our findings suggested that low levels of neutralizing antibodies against BA.5 subbranches before the pandemic might have contributed to the national outbreak at the end of 2022. The widespread breakthrough infections subsequently increased immunity to BA.5, XBB.1.5/1.9.1, and JN.1, inhibiting a new wave of large-scale infections caused by XBB subbranches in China. Addi

SUBMITTER: Du P 

PROVIDER: S-EPMC11464334 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature