Changes of brain structure and structural covariance networks in Parkinson's disease associated cognitive impairment.

ABSTRACT:

Background

Cognitive impairment (CI) is common in Parkinson's disease (PD). Multiple brain regions and their interactions are involved in PD associated CI. Magnetic resonance imaging (MRI) technology is a non-invasive method in investigating brain structure and inter-regional connections. In this study, by comparing cortical thickness, subcortical volume, and brain network topology properties in PD patients with and without CI, we aimed to understand the changes of brain structure and structural covariance network properties in PD associated CI.

Methods

A total of 18 PD patients with CI and 33 PD patients without CI were recruited. Movement Disorder Society Unified Parkinson's Disease Rating Scale, Hoehn and Yahr stage, Mini Mental State Examination Scale, Non-motor Symptom

SUBMITTER: Liu RP 

PROVIDER: S-EPMC11464354 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature