A population code for spatial representation in the zebrafish telencephalon.

ABSTRACT: Spatial learning in teleost fish requires an intact telencephalon¹, a brain region that contains putative analogues to components of the mammalian limbic system (for example, hippocampus)^2-4. However, cells fundamental to spatial cognition in mammals-for example, place cells (PCs)^5,6-have yet to be established in any fish species. In this study, using tracking microscopy to record brain-wide calcium activity in freely swimming larval zebrafish⁷, we compute the spatial information content⁸ of each neuron across the brain. Strikingly, in every recorded animal, cells with the highest spatial specificity were enriched in the zebrafish telencephalon. These PCs form a population code of space from which we can decode the animal's spatial loc

SUBMITTER: Yang C 

PROVIDER: S-EPMC11464381 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature