Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis.

ABSTRACT: Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk¹. Furthermore, LDL-C fluctuations are associated with ASCVD outcomes^2-4. However, the precise mechanisms behind this increased ASCVD risk are not understood. Here we find that early intermittent feeding of mice on a high-cholesterol Western-type diet (WD) accelerates atherosclerosis compared with late continuous exposure to the WD, despite similar cumulative circulating LDL-C levels. We find that early intermittent hyperlipidaemia alters the number a

SUBMITTER: Takaoka M 

PROVIDER: S-EPMC11464399 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature