VirTAXA: enhancing RNA virus taxonomic classification with remote homology search and tree-based validation.

ABSTRACT:

Summary

RNA viruses are ubiquitous across a broad spectrum of ecosystems. Therefore, beyond their significant implications for public health, RNA viruses are also key players in ecological processes. High-through sequencing has accelerated the discovery of RNA viruses. Nevertheless, many of these viruses lack taxonomic annotation, posing a challenge to functional inference and evolutionary study. In particular, virus classification at the genus level remains difficult due to the limited reference data and ambiguous boundaries between some closely related genera. We introduce VirTAXA, a robust classification tool that combines remote homology search and tree-based validation to enhance the genus-level taxonomic classification of RNA viruses. VirTAXA is able to predict the genus labe

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11464415 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature