A pig model exploring the postnatal hair follicle cycle.

ABSTRACT:

Introduction

The hair follicle (HF) is a micro-organ capable of regeneration. A HF cycle consists of an anagen, catagen and telogen. Abnormalities in the HF cycle can lead to many hair disorders such as hair loss. The pig is a good biomedical model, but there are few data on their HF cycle. The aim of this study was to classify the pig HF cycle and determine the feasibility of the pig as an animal model for human HF cycle.

Methods

Skin samples from 10 different postnatal (P) days Yorkshire pigs was collected to determine the key time points of the first HF cycle in pig by H&E staining, immunofluorescence staining, q-PCR and western-blot.

Results

By morphological observation and detection of markers at different stages, pig HF cycle was classified into three main perio

SUBMITTER: Li S 

PROVIDER: S-EPMC11464431 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature