Rate of motor progression in Parkinson's disease: a systematic review and meta-analysis.

ABSTRACT:

Background

The search for neuroprotective treatments for Parkinson's disease (PD) still relies largely on motor disability scales. A limitation of these tools is the strong influence of symptomatic dopaminergic treatment effects. Drawing on a wealth of published information, we conducted a systematic review and meta-analysis of motor progression in PD and its relationships with dopaminergic therapy.

Methods

We searched Medline, Embase, and Central to identify 84 publications with adequate serial motor scores to calculate progression, expressed as an increase in the percentage of maximum disability.

Results

A random-effects model showed motor progression at 2.0% p.a. (95% CI 1.7-2.4%). There were no significant differences by baseline age, sample size, or observation p

SUBMITTER: Pauwels A 

PROVIDER: S-EPMC11464440 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature