Dual-responsive nanoplatform for integrated cancer diagnosis and therapy: Unleashing the power of tumor microenvironment.

ABSTRACT: Chemodynamic therapy (CDT), designed to trigger a tumor-specific hydrogen peroxide (H₂O₂) reaction generating highly toxic hydroxyl radicals (·OH), has been investigated for cancer treatment. Unfortunately, the limited Fenton or Fenton-like reaction rate and the significant impact of excessive reducing glutathione (GSH) in the tumor microenvironment (TME) have severely compromised the effectiveness of CDT. To address this issue, we designed a dual-responsive nanoplatform utilizing a metal-polyphenol network (MPN) -coated multi-caged IrO_x for efficient anti-tumor therapy in response to the acidic TME and intracellular excess of GSH, in which MPN composed of Fe³⁺ and tannic acid (TA). Initially, the acidic TME and intracellular excess of GSH lead t

SUBMITTER: Ma R 

PROVIDER: S-EPMC11464441 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature