In pre-clinical study fetal hypoxia caused autophagy and mitochondrial impairment in ovary granulosa cells mitigated by melatonin supplement.

ABSTRACT:

Introduction

Fetal hypoxia has long-term effects on postnatal reproductive functions and the mitochondrial impairments of ovarian granulosa cells may be one of the causes. Melatonin applied to mitigate mitochondrial dysfunction and autophagy in mammalian cells has been reported. However, the potential mechanisms by which fetal hypoxia damages reproductive function in neonatal female mice and the melatonin effects on this problem remain unclear.

Objectives

This research aimed to explore the mechanism that fetal hypoxia damages reproductive function in neonatal female mice and attempt to improve the reproductive function by treating with melatonin in vivo and in vitro.

Methods

We established a fetal hypoxia model and confirmed that fetal hypoxia affects ovarian function

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11464463 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature