Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson's disease models.

ABSTRACT:

Introduction

Parkinson's disease (PD) is common neurodegenerative disease where oxidative stress and mitochondrial dysfunction play important roles in its progression. Tetramethylpyrazine nitrone (TBN), a potent free radical scavenger, has shown protective effects in various neurological conditions. However, the neuroprotective mechanisms of TBN in PD models remain unclear.

Objectives

We aimed to investigate TBN's neuroprotective effects and mechanisms in PD models.

Methods

TBN's neuroprotection was initially measured in MPP⁺/MPTP-induced PD models. Subsequently, a luciferase reporter assay was used to detect peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) promoter activity. Effects of TBN on antioxidant damage and the PGC-1α/Nuclear f

SUBMITTER: Guo B 

PROVIDER: S-EPMC11464467 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature