Activation of mitochondrial aldehyde dehydrogenase 2 promotes hair growth in human hair follicles.

ABSTRACT:

Introduction

Hair loss is a common phenomenon associated with various environmental and genetic factors. Mitochondrial dysfunction-induced oxidative stress has been recognized as a crucial determinant of hair follicle (HF) biology. Aldehyde dehydrogenase 2 (ALDH2) mitigates oxidative stress by detoxifying acetaldehyde. This study investigated the potential role of ALDH2 modulation in HF function and hair growth promotion.

Objectives

To evaluate the effects of ALDH2 activation on oxidative stress in HFs and hair growth promotion.

Methods

The modulatory role of ALDH2 on HFs was investigated using an ALDH2 activator. ALDH2 expression in human HFs was evaluated through in vitro immunofluorescence staining. Ex vivo HF organ culture was employed to assess hair shaft elongat

SUBMITTER: Lee S 

PROVIDER: S-EPMC11464481 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature