Complex transcriptional regulations of a hyperparasitic quadripartite system in giant viruses infecting protists.

ABSTRACT: Hyperparasitism is a common pattern in nature that is not limited to cellular organisms. Giant viruses infecting protists can be hyperparasitized by smaller ones named virophages. In addition, both may carry episomal DNA molecules known as transpovirons in their particles. They all share transcriptional regulatory elements that dictate the expression of their genes within viral factories built by giant viruses in the host cytoplasm. This suggests the existence of interactions between their respective transcriptional networks. Here we investigated Acanthamoeba castellanii cells infected by a giant virus (megavirus chilensis), and coinfected with a virophage (zamilon vitis) and/or a transpoviron (megavirus vitis transpoviron). Infectious cycles were monitored through time-course RNA sequenci

SUBMITTER: Bessenay A 

PROVIDER: S-EPMC11464507 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature