Mechanisms of HIF1A-mediated immune evasion in gastric cancer and the impact on therapy resistance.

ABSTRACT:

Background

The high prevalence and detrimental effects on patient outcomes make gastric cancer (GC) a significant health issue that persists internationally. Existing treatment modalities exhibit limited efficacy, prompting the exploration of immune checkpoint inhibitors as a novel therapeutic approach. However, resistance to immunotherapy poses a significant challenge in GC management, necessitating a profound grasp of the intrinsic molecular pathways.

Methods

This study focuses on investigating the immunosuppressive mechanisms of quiescent cancer cells (QCCs) in GC, particularly their resistance to T-cell-mediated immune responses. Utilizing mouse models, gene editing techniques, and transcriptome sequencing, we aim to elucidate the interactions between QCCs, immune cells,

SUBMITTER: Qi H 

PROVIDER: S-EPMC11464584 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature