Adaptive optics scanning laser ophthalmoscopy in a heterogenous cohort with Stargardt disease.

ABSTRACT: Image based cell-specific biomarkers will play an important role in monitoring treatment outcomes of novel therapies in patients with Stargardt (STGD1) disease and may provide information on the exact mechanism of retinal degeneration. This study reports retinal image features from conventional clinical imaging and from corresponding high-resolution imaging with a confocal adaptive optics scanning laser ophthalmoscope (AOSLO) in a heterogenous cohort of patients with Stargardt (STGD1) disease. This is a prospective observational study in which 16 participants with clinically and molecularly confirmed STGD1, and 7 healthy controls underwent clinical assessment and confocal AOSLO imaging. Clinical assessment included short-wavelength and near-infrared fundus autofluorescence, spectral-domain

SUBMITTER: Shah M 

PROVIDER: S-EPMC11464663 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature