The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development.

ABSTRACT: The paralogs 9-13 Hox genes in mouse HoxA and HoxD clusters are critical for limb development. When both HoxA and HoxD clusters are deleted in mice, significant limb truncation is observed compared to the phenotypes of single and compound mutants of Hox9-13 genes in these clusters. In zebrafish, mutations in hox13 genes in HoxA- and HoxD-related clusters result in abnormal morphology of pectoral fins, homologous to forelimbs. However, the effect of the simultaneous deletions of entire HoxA- and HoxD-related clusters on pectoral fin development remains unknown. Here, we generated mutants with several combinations of hoxaa, hoxab, and hoxda cluster deletions and analyzed the pectoral fin development. In hoxaa^-/-;hoxab^-/-;hoxda^-/- larvae, the endoskeletal disc

SUBMITTER: Ishizaka M 

PROVIDER: S-EPMC11464670 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature