Modeling transmission mechanism to infer treatment efficacy of different drugs and combination therapy against Trichuris trichiura.

ABSTRACT: Trichuris trichiura is one of four soil-transmitted helminth species that, collectively, are responsible for a considerable public health burden. The World Health Organization recommends preventive chemotherapy as the main intervention to eliminate soil-transmitted helminthiasis as a public health problem. Clinical trials estimated the efficacy of different drugs and treatment regimen against T. trichiura and other soil-transmitted helminth species, whilst meta-analyses and modeling efforts were conducted to determine the most efficacious drugs and drug combinations. Of note, the diagnostic error was often neglected, and hence, cure rates (CRs) might be overestimated. We developed a Bayesian model, which estimates drug efficacy against T. trichiura, taking into account the transmission mec

SUBMITTER: Grolimund CM 

PROVIDER: S-EPMC11464734 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature