GWAS Meta-analysis of Kidney Function Traits in Japanese Populations.

ABSTRACT:

Background

Genetic epidemiological evidence for the kidney function traits in East Asian populations, including Japanese, remain still relatively unclarified. Especially, the number of genome-wide association studies (GWASs) for kidney traits reported still remains limited, and the sample size of each independent study is relatively small. Given the genetic variability between ancestries/ethnicities, implementation of GWAS with sufficiently large sample sizes in specific population of Japanese is considered meaningful.

Methods

We conducted the GWAS meta-analyses of kidney traits by leveraging the GWAS summary data of the representative large genome cohort studies with about 200,000 Japanese participants (n = 202,406 for estimated glomerular filtration rate [eGFR] and n = 200

SUBMITTER: Hishida A 

PROVIDER: S-EPMC11464852 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature