Task-evoked pupillary responses as potential biomarkers of mild cognitive impairment.

ABSTRACT:

Introduction

Eye movement alterations are effective biomarkers for Alzheimer's disease (AD). This study examines task-evoked pupillary responses (TEPRs) as potential biomarkers of the mild cognitive impairment (MCI), the symptomatic stage preceding AD.

Methods

The prospective cohort study included 213 MCI patients and 514 cognitively normal controls (CNs). Participants performed a prosaccade (PS) or antisaccade (AS) task while their eye movements were tracked using a Tobii Pro Spectrum system.

Results

The CNs showed unique TEPRs linked to better performance, characterized by larger baselines, greater PS target-onset variability, and smaller AS target-onset variability. Conversely, for MCI patients, better performance was linked to larger AS target-onset sizes. Further

SUBMITTER: Opwonya J 

PROVIDER: S-EPMC11465026 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature