Genetic Susceptibility to Hidradenitis Suppurativa and Predisposition to Cardiometabolic Disease.

ABSTRACT:

Importance

Hidradenitis suppurativa (HS) is associated with an increased prevalence of cardiovascular diseases compared with the general population. Any association between polygenic risk for HS, risk of incident cardiometabolic outcomes, and the plasma proteome is unclear.

Objective

To investigate the genetic correlation between HS and cardiometabolic disease.

Design, setting, and participants

This cohort study used a polygenic risk score (PRS) for HS to examine the risks of coronary artery disease (CAD) and diabetes and identify changes in the plasma proteome in individuals of European ancestry from the UK Biobank. Participants were enrolled from January 1, 2006, to December 31, 2010. End of follow-up was January 1, 2023. Correlations were assessed between HS suscep

SUBMITTER: Nielsen VW 

PROVIDER: S-EPMC11465120 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature