Synthesis and Evaluation of Thiazolyl-indole-2-carboxamide Derivatives as Potent Multitarget Anticancer Agents.

ABSTRACT: Cancer is a complex disease driven by the dysregulation of multiple signaling pathways and cellular processes. The development of compounds capable of exerting multitarget actions against these key pathways involved in cancer progression is a promising therapeutic approach. Here, a series of novel (E/Z)-N-(4-(2-(2-(substituted)hydrazineyl)-2-oxoethyl)thiazol-2-yl)-1H-indole-2-carboxamide derivatives (6a-6z) were designed, synthesized, and evaluated for their biological activity. Compounds 6e, 6i, 6q, 6v, 7a, and 7b exhibited exceptional cytotoxicity against various cancer cell lines, particularly 6i (IC₅₀ = 6.10 ± 0.4 μM against MCF-7 cell lines) and 6v (IC₅₀ = 6.49 ± 0.3

SUBMITTER: Saadan NM 

PROVIDER: S-EPMC11465279 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature