Topical Vitamin D Prevents Bone Loss and Inflammation in a Mouse Model.

ABSTRACT: There is a strong association between vitamin D levels and periodontal disease based on numerous epidemiological studies. We have previously shown that experimental deficiency of serum vitamin D in mice leads to gingival inflammation and alveolar bone loss. Treatment of cultured oral epithelial cells with the active form of vitamin D, 1,25(OH)₂ vitamin D₃ (1,25(OH)₂D₃), inhibits the extracellular growth and intracellular invasion of bacteria associated with periodontal disease. Maintenance of periodontal health may be due in part to the anti-inflammatory activities of vitamin D. Furthermore, this hormone can induce the expression of an antimicrobial peptide in cultured oral epithelial cells. We have shown that oral epithelial cells are capable of

SUBMITTER: Kirkwood KL 

PROVIDER: S-EPMC11465324 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature