Risk factors and epidemiology of spontaneous intestinal perforation among infants born at 22-24 weeks' gestational age.

ABSTRACT:

Objective

To describe the epidemiology, risk factors, and timing of spontaneous intestinal perforation (SIP) among infants born at 22-24 weeks' gestational age (GA).

Study design

Observational cohort study among infants born at 22-24 weeks' GA in 446 neonatal intensive care units.

Results

We identified 9712 infants, of whom 379 (3.9%) developed SIP. SIP incidence increased with decreasing GA (P < 0.001). Antenatal magnesium (odds ratio (OR) 1.42; 95% confidence interval (CI), 1.09-1.85), antenatal indomethacin (OR 1.40; 95% CI, 1.06-1.85), postnatal indomethacin (OR 1.61; 95% CI, 1.23-2.11), and postnatal hydrocortisone exposure (OR 2.02; 95% CI 1.50-2.73) were associated with SIP. Infants who lost 15-20% (OR 1.77; 95% CI, 1.28-2.44) or >20% (OR 2.04; 95% CI, 1.46-2.8

SUBMITTER: Thakkar PV 

PROVIDER: S-EPMC11465378 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature