KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion.

ABSTRACT:

Background

Recurrent spontaneous abortion (RSA) is defined as two or more consecutive spontaneous abortions before 20 weeks with the same spouse [1]. However, approximately 50% of RSA cases of unknown cause are classified as unexplained recurrent spontaneous abortion (URSA). Potential factors include decreased trophoblast cell migration and invasion, leading to impaired placental implantation and maintenance of the normal maternal-fetal interface. However, the mechanism of this pathogenesis remains unknown. In this study, we investigated the potential role and mechanism of KLF4 in regulating URSA by influencing the invasion and migration ability of trophoblast cells.

Methods

We firstly identified 817 differentially expressed genes by performing a difference analysis of the d

SUBMITTER: Tan Y 

PROVIDER: S-EPMC11465507 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature