PPARγ/ETV2 axis regulates endothelial-to-mesenchymal transition in pulmonary hypertension.

ABSTRACT: Endothelial-to-mesenchymal transition (EndoMT) plays an important role in pulmonary hypertension (PH) but the molecular mechanisms regulating EndoMT remain to be defined. We demonstrate that the axis of the transcription factors PPARγ (Peroxisome Proliferator-Activated Receptor gamma) and ETV2 (ETS variant 2) play important roles in the pathogenesis of PH. Decreased levels of the expression of PPARγ and ETV2 along with reduced endothelial and increased EndoMT markers are consistently observed in lungs and pulmonary artery endothelial cells (PAECs) of idiopathic pulmonary arterial hypertension patients, in hypoxia-exposed mouse lungs, human PAECs, and in induced-EndoMT cells. Etv2 ^+/- mice spontaneously developed PH and right ventricular hypertrophy (RVH), associate

SUBMITTER: Lee DH 

PROVIDER: S-EPMC11465559 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature