Two Different Responsive Organosilica Nanocarriers to Combine Chemo- and Immunotherapy against Cancer.

ABSTRACT: The combination of chemo- and immunotherapy was recently demonstrated to improve a patient's response to therapy, giving rise to an emerging cancer treatment known as chemoimmunotherapy (CIT). Despite the promising benefits of CIT, the most important challenges are (i) the simultaneous or time-controlled delivery of two drugs and (ii) the selective uptake into different cells for each of the drugs: cancer cells for the chemotherapeutic and macrophages for the immunostimulation actives. Herein, a delivery strategy based on morphologically different stimuli-responsive breakable organosilica nanocarriers is exploited to transport two distinct drugs in the different cells using different times of delivery. We employ stimulus-sensitive, PEGylated organosilica nanocages to encapsulate the chemot

SUBMITTER: Sancho-Albero M 

PROVIDER: S-EPMC11465578 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature