Entrapment of Amphipathic Drugs in Core-Shell Polymeric Nanoparticles under Batch Conditions─The Role of Control and Solubility Parameters.

ABSTRACT: The amphipathic bioactive compounds curcumin, resveratrol, and mitomycin C, which have similar solubility parameter component distributions, have been studied for encapsulation under batch conditions into core-shell nanocarriers composed of external hydrophobically functionalized polyelectrolytes and an inner matrix of polyesters or polyester blends: poly(l-lactide), poly(lactide-co-glycolide), and/or poly(ethylene succinate). Our contribution comprises determining the influence of process parameters on the properties and quality of the final products, namely core-shell nanoparticles loaded with appropriate drugs, according to process analysis technologymanagement. The crucial roles of the organic phase dosing rates and process temperatures were carefully investigated. Moreover, a t

SUBMITTER: Lamch L 

PROVIDER: S-EPMC11465662 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature