Donor age over 55 is associated with worse outcome in lung transplant recipients with idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Lung transplantation (LTx) remains the only efficient treatment for selected patients with end-stage pulmonary disease. The age limit for the acceptance of donor organs in LTx is still a matter of debate. We here analyze the impact of donor organ age and the underlying pulmonary disease on short- and long-term outcome and survival after LTx.

Methods

Donor and recipient characteristics of LTx recipients at our institution between 03/2003 and 12/2021 were analyzed. Statistical analysis was performed using SPSS and GraphPad software.

Results

In 230 patients analyzed, donor age ≥ 55 years was associated with a higher incidence of severe primary graft dysfunction (PGD2/3) (46% vs. 31%, p = 0.03) and reduced long-term survival after LTx (1-, 5- and 10-year surviv

SUBMITTER: Moneke I 

PROVIDER: S-EPMC11465681 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature