Identification and experimental validation of a sialylation-related long noncoding RNA signature for prognosis of bladder cancer.

ABSTRACT:

Background

The dysregulation of sialylation plays a pivotal role in cancer progression and metastasis, impacting various aspects of tumor behavior. This study aimed to investigate the prognostic significance of long non-coding RNAs (lncRNAs) in relation to sialylation. Additionally, we aimed to develop a signature of sialylation-related lncRNAs in the context of bladder cancer.

Methods

This study used transcriptomic data and clinical information from the TCGA (the Cancer Genome Atlas) database to screen for sialylation-related lncRNAs and constructed a prognostic model. The relationships between these lncRNAs and biological pathways, immune cell infiltration, drug sensitivity, etc., were analyzed, and the expression of some lncRNAs was validated at the cellular level.

Res

SUBMITTER: Qiao Y 

PROVIDER: S-EPMC11465731 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature