Tumor specific in situ synthesis of therapeutic agent for precision cancer therapy.

ABSTRACT:

Background

Traditional chemotherapeutic agents suffer from a lack of selectivity, poor targeting ability, and drug resistance. Developing tumor-specific therapies is crucial for precisely eliminating tumors while circumventing toxicity to normal tissues. Disulfiram (DSF), an FDA-approved drug for treating alcohol dependence, exhibits antitumor effect by forming complexes with copper ions (Cu(DDC)₂). Here, we developed a Cu-doped polydopamine-based nanosystem (DSF@CuPDA-PEGM) to achieve in situ generation of toxic Cu(DDC)₂.

Results

In cancer cells with elevated H₂O₂ contents, CuPDA responsively degrades to release Cu ions and DSF, allowing on-site synthesis of Cu(DDC)₂ with potent antitumor activity. DSF@CuPDA-PEGM exhibi

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC11465910 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature