Mutational analysis differentiating sporadic carcinomas from colitis-associated colorectal carcinomas.

ABSTRACT:

Background

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that is associated with increased risk of developing colitis-associated carcinoma (CAC). The genetic profile of CACs is fairly similar to the sporadic colorectal carcinomas (sCRCs), although showing certain differences in the timing and sequence of alterations that contribute to carcinogenesis. Also, both cancer types typically show a strong histological resemblance, which complicates the pathologists' diagnosis. Due to the different clinical consequences, it is of utmost importance to categorize the corresponding cancer type correctly.

Methods

In this study, we determined the mutation profiles of 64 CACs and sCRCs in the hotspot regions of 50 cancer-associated genes and compared them to 29 cont

SUBMITTER: Dregelies T 

PROVIDER: S-EPMC11465924 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature