Circulating levels of cytokines and risk of urologic cancers: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Chronic inflammation is associated with the etiology of various cancers. However, there is a lack of systematic research in urologic cancers. This study aims to use a two-sample Mendelian randomization (MR) approach to evaluate the role of circulating cytokines in the development of urologic cancers.

Methods

We obtained the summary-level data for bladder cancer (373,295 cases and 372,016 controls), prostate cancer (462,933 cases and 459,664 controls), and kidney cancer (463,010 cases and 461,896 controls) from the UK Biobank. Genetic variations linked to 41 circulating cytokines were used as instrumental variables (IVs) in meta-analyses of genome-wide association studies (GWASs) involving 8,293 individuals from Finland. We primarily used the inverse-variance weigh

SUBMITTER: Song J 

PROVIDER: S-EPMC11465925 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature