AIMP2 accumulation in brain leads to cognitive deficits and blood secretion in Parkinson's disease.

ABSTRACT:

Background

Propagation of neuronal α-synuclein aggregate pathology to the cortex and hippocampus correlates with cognitive impairment in Parkinson's disease (PD) dementia and dementia with Lewy body disease. Previously, we showed accumulation of the parkin substrate aminoacyl-tRNA synthetase interacting multifunctional protein-2 (AIMP2) in the temporal lobe of postmortem brains of patients with advanced PD. However, the potential pathological role of AIMP2 accumulation in the cognitive dysfunction of patients with PD remains unknown.

Methods

We performed immunofluorescence imaging to examine cellular distribution and accumulation of AIMP2 in brains of conditional AIMP2 transgenic mice and postmortem PD patients. The pathological role of AIMP2 was investigated in the AIMP2 tr

SUBMITTER: Kim H 

PROVIDER: S-EPMC11465931 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature