Protein-protein interaction network-based integration of GWAS and functional data for blood pressure regulation analysis.

ABSTRACT:

Background

It is valuable to analyze the genome-wide association studies (GWAS) data for a complex disease phenotype in the context of the protein-protein interaction (PPI) network, as the related pathophysiology results from the function of interacting polyprotein pathways. The analysis may include the design and curation of a phenotype-specific GWAS meta-database incorporating genotypic and eQTL data linking to PPI and other biological datasets, and the development of systematic workflows for PPI network-based data integration toward protein and pathway prioritization. Here, we pursued this analysis for blood pressure (BP) regulation.

Methods

The relational scheme of the implemented in Microsoft SQL Server BP-GWAS meta-database enabled the combined storage of: GWAS data an

SUBMITTER: Tsare EG 

PROVIDER: S-EPMC11465932 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature