Cystine crystal nucleation and decay in the context of cystinuria pathogenesis and treatment.

ABSTRACT: Cystinuria is a rare disease which results in the precipitation of cystine in the renal filtrate, which may cause acute kidney injury due to mechanical trauma. In this work, we attempt to explore the origin of supersaturated cystine in this context to understand disease pathogenesis. This has enabled us to reproduce the clinical habit of cystine following a comprehensive study of cystine nucleation and growth in saline, artificial and human urine. Then, we describe the physical behaviour of these crystals in the presence of: cysteamine, sodium bicarbonate, captopril, tiopronin, penicillamine, glutathione and α-lipoic acid. Surprisingly, we observe that, in vitro, only cysteamine and saturated sodium bicarbonate dissolve crystals at a faster rate than saline, and that when solution p

SUBMITTER: Noble K 

PROVIDER: S-EPMC11465997 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature