Assessment of Atherothrombotic Risk in Patients With Type 2 Diabetes Mellitus.

ABSTRACT:

Background

Risk of atherothrombotic events is not uniform in patients with type 2 diabetes mellitus (T2DM). Tailored risk assessment may help guide selection of pharmacotherapies for cardiovascular primary and secondary prevention.

Objectives

The purpose of this study was to develop a risk model for atherothrombosis in patients with T2DM.

Methods

We developed and validated a risk model for myocardial infarction (MI) or ischemic stroke (IS) in a pooled cohort of 42,181 patients with T2DM from 4 TIMI (Thrombolysis In Myocardial Infarction) clinical trial cohorts. Candidate variables were assessed with multivariable Cox regression, and independent variables (P < 0.05) were retained in the final model. Discrimination and calibration were assessed. Treatment interactions w

SUBMITTER: Berg DD 

PROVIDER: S-EPMC11466046 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature