Exposure to Air Pollutants and Myocardial Infarction Incidence: A UK Biobank Study Exploring Gene-Environment Interaction.

ABSTRACT:

Background

Unraveling gene-environment interaction can provide a novel insight into early disease prevention. Nevertheless, current understanding of the interplay between genetic predisposition and air pollution in relation to myocardial infarction (MI) risk remains limited. Furthermore, the potential long-term influence of air pollutants on MI incidence risk warrants more conclusive evidence in a community population.

Objective

We investigated interactions between genetic predisposition and exposure to air pollutants on MI incidence.

Methods

This study incorporated a sample of 456,354 UK Biobank participants and annual mean air pollution (PM2.5, PM10, NO2, and NOx) from the UK Department for Environment, Food and Rural Affairs (2006-2021). The Cox proportional hazard

SUBMITTER: Ma Y 

PROVIDER: S-EPMC11466320 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature