Male Akita diabetic mice develop underactive bladder independent of NLRP3 that can be prevented with blood glucose control.

ABSTRACT:

Aim

Diabetic bladder dysfunction (DBD) is the most common diabetic complication. Patients present with overactive symptoms, underactive symptoms, or both. While strict glucose control may be expected to reverse DBD, prior studies have not been supportive. However, we hypothesize that strict control, soon after hyperglycemia appears, can prevent DBD development. Moreover, 50% of adult diabetics are poorly-controlled and it is unknown how this effects development of DBD. Thus, we investigated the effect of early glucose control (poor and strict) on DBD in male Akita diabetic mice (type 1). NLRP3-induced inflammation is critical to development of DBD in female Akita. Therefore, we also hypothesized that targeting NLRP3 may control or prevent DBD in male Akita, especially in a poorly-c

SUBMITTER: Livingston AJ 

PROVIDER: S-EPMC11466384 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature