From genes to reproductive health: Immune cell influences on abortion.

ABSTRACT:

Background

The relationship between dysregulation of the immune system and reproductive health, particularly in the context of abortion, is an area of critical research. Identifying the immunological factors that contribute to abortion could provide valuable insights into its prevention and management.

Methods

This study used bidirectional two-sample Mendelian Randomization (MR) approach to evaluate the causal link between 731 immune cell features and the risk of abortion. The study analyzed GWAS data from 257,561 Europeans, including 7,069 cases and 250,492 controls, by utilizing genetic variation as instrumental variables. The immune phenotypes included several cell types, including B cells, T cells, TBNK cells, Treg cells, and monocytes. These were analyzed using the 'Two

SUBMITTER: Shen D 

PROVIDER: S-EPMC11466425 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature