The Role of Magnesium in Acute Pancreatitis and Pancreatic Injury: A Systematic Review.

ABSTRACT:

Introduction

As natural calcium (Ca) antagonist, magnesium (Mg) seems to counteract Ca-signaling pathways involved in the intracellular protease activation leading to acute pancreatitis. We systematically reviewed the current literature to investigate the role of Mg in the pathogenesis of acute pancreatitis and its possible use in detecting, predicting, and preventing acute pancreatitis.

Methods

A systematic search was performed in PubMed/Scopus/Web of Science to identify in vivo and in vitro studies reporting data on Mg in acute pancreatitis.

Results

Twelve studies were included. Due to their heterogeneity, we conducted a review without the intent of inference. Mg deficiency in pancreatic acinar cells seems to be frequently associated with serum hypocalcemia and acut

SUBMITTER: Pergolini I 

PROVIDER: S-EPMC11466448 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature