Landscape of epithelial cell subpopulations in the human esophageal squamous cell carcinoma microenvironment.

ABSTRACT:

Aims

We sought to reveal the landscape of epithelial cell subpopulations in the human esophageal squamous cell carcinoma microenvironment and investigate their parts on esophageal squamous carcinoma (ESCC) development.

Background

Epithelial cells play an important role in the occurrence and development of ESCC through multiple mechanisms. While the landscape of epithelial cell subpopulations in ESCC, remains unclear.

Objective

Exploring the role of epithelial cell subpopulations in ESCC progression.

Methods

Seurat R package was used for single-cell RNA sequencing (scRNA-seq) data filtering, dimensionality reduction, clustering and differentially expressed genes analysis. Cellmarker database was adopted for cell cluster annotation. Functional enrichment analysis

SUBMITTER: Yang J 

PROVIDER: S-EPMC11466536 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature