MiR-6884-5p inhibits proliferation and epithelial-mesenchymal transition in non-small cell lung cancer cells.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is associated with a high mortality and morbidity rate. MicroRNAs participate in tumorigenesis, progression and metastasis of NSCLC. However, miR-6884-5p has not been previously studied. This study aimed to investigate the role of miR-6884-5p in NSCLC and explore its underlying mechanisms.

Methods

We used miR-6884-5p mimics and inhibitors to assess its effects in NSCLC. miR-6884-5p expression levels in NSCLC cell lines were quantified using qRT-PCR. Cell viability was determined using a cell-counting kit 8 assay. Western blot analysis was employed to measure apoptotic proteins. The impact of miR-6884-5p on cell proliferation was assessed via colony formation assay. Furthermore, Transwell assays were utilized to visualize and quan

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11466542 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature