Reduced-distortion diffusion weighted imaging for head and neck radiotherapy.

ABSTRACT:

Background and purpose

Quantitative Diffusion Weighted Imaging (DWI) has potential value in guiding head and neck (HN) cancer radiotherapy. However, clinical translation has been hindered by severe distortions in standard single-shot Echo-Planar-Imaging (ssEPI) and prolonged scan time and low SNR in Turbo-Spin-Echo (ssTSE) sequences. In this study, we evaluate "multi-shot" (ms) msEPI and msTSE acquisitions in the context of HN radiotherapy.

Materials and methods

ssEPI, ssTSE, msEPI with 2 and 3 shots (2sEPI, 3sEPI), and msTSE DWI were acquired in a phantom, healthy volunteers (N=10), and patients with HN cancer (N=5) on a 3-Tesla wide-bore MRI in radiotherapy simulation RF coil setup, with matched spatial resolution (2x2x5mm) and b = 0, 200, 800 s/mm².Geometric di

SUBMITTER: Aliotta E 

PROVIDER: S-EPMC11466654 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature