Myeloid-Specific JAK2 Contributes to Inflammation and Salt Sensitivity of Blood Pressure.

ABSTRACT:

Background

Salt sensitivity of blood pressure (SSBP), characterized by acute changes in blood pressure with changes in dietary sodium intake, is an independent risk factor for cardiovascular disease and mortality in people with and without hypertension. We previously found that elevated sodium concentration activates antigen-presenting cells (APCs), resulting in high blood pressure, but the mechanisms are unknown. Here, we hypothesized that APC-specific JAK2 (Janus kinase 2) through STAT3 (signal transducer and activator of transcription 3) and SMAD3 (small mothers against decapentaplegic homolog 3) contributes to SSBP.

Methods

We performed bulk or single-cell transcriptomic analyses following in vitro monocytes exposed to high salt and in vivo high sodium treatment in human

SUBMITTER: Saleem M 

PROVIDER: S-EPMC11466692 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature