The causal relationship between immune cell traits and schizophrenia: a Mendelian randomization analysis.

ABSTRACT:

Introduction

The complex and unresolved pathogenesis of schizophrenia has posed significant challenges to its diagnosis and treatment. While recent research has established a clear association between immune function and schizophrenia, the causal relationship between the two remains elusive.

Methods

We employed a bidirectional two-sample Mendelian randomization approach to investigate the causal relationship between schizophrenia and 731 immune cell traits by utilizing public GWAS data. We further validated the causal relationship between schizophrenia and six types of white cell measures.

Results

We found the overall causal effects of schizophrenia on immune cell traits were significantly higher than the reverse ones (0.011 ± 0.049 vs 0.001 ± 0.016, p < 0.001), imply

SUBMITTER: Du J 

PROVIDER: S-EPMC11466782 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature