Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling.

ABSTRACT: The integration of spatial omics technologies can provide important insights into the biology of tissues. Here we combined mass spectrometry imaging-based metabolomics and imaging mass cytometry-based immunophenotyping on a single tissue section to reveal metabolic heterogeneity at single-cell resolution within tissues and its association with specific cell populations such as cancer cells or immune cells. This approach has the potential to greatly increase our understanding of tissue-level interplay between metabolic processes and their cellular components.

SUBMITTER: Nunes JB 

PROVIDER: S-EPMC11466816 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature